CRISPR-based gene therapy reduces tumor growth by 50% in models


 Researchers at UNIST and the Institute for Basic Science have unveiled a novel cancer gene therapy that leverages CRISPR/Cas9 to induce precise single-strand breaks (SSBs) in cancer cell DNA. Unlike traditional methods that create double-strand breaks, this technique simplifies the editing process and significantly lowers the risk of off-target effects. By using just four guide RNAs and incorporating PARP inhibitors—drugs that block DNA repair—the therapy effectively prevents cancer cells from fixing the damage, triggering cell death.

The study reports a reduction in tumor growth of over 50% in mouse models and demonstrates efficacy in patient-derived organoids. Notably, the inclusion of PARP inhibitors allows this approach to target a broader range of cancers beyond those with specific BRCA mutations. The researchers suggest that this strategy could be combined with radiation therapy to maintain treatment efficacy while reducing debilitating side effects, paving the way for more personalized oncological interventions.
Read the original article at: https://medicalxpress.com/news/2025-09-gene-technology-enables-destruction-cancer.html


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